These biomarkers encompass key renal function parameters (e.g., CRE, EGFR), indicators of serum uric acid homeostasis (URNA and UA), serum calcium concentration (CA), lipid metabolism‐related markers such as HDL and ApoA and the amino acid Cys, which has been less frequently linked to kidney stone prevention in prior studies. The gene discussed is EGFR; the disease is nephrolithiasis.