Concurrently, six protein ratio pairs were found to inhibit kidney stone occurrence: GGT1/MME protein level ratio, ACE2/MME protein level ratio, ITIH3/VCAM1 protein level ratio, GZMA/TNFRSF8 protein level ratio, CRADD/HSPA1A protein level ratio and GZMA/TNFRSF4 protein level ratio. The gene discussed is ACE2; the disease is nephrolithiasis.