RELA and chronic kidney disease: The significant reduction of p‐p65 inhibited the nuclear translocation process of NF‐κB and hindered its subsequent signal transduction, thus reducing the expression levels of ubiquitin ligases MurF1 and MAFbx in the muscle of CKD rats and LPS‐induced C2C12 myoblasts, thereby inhibiting protein catabolism and ameliorating skeletal muscle wasting.