In pancreatic cancer cells, autophagy is linked to Integrin Subunit Beta 4 (ITGB4)‐ BCL2 interacting protein 3 (BNIP3) expression, with ITGB4/BNIP3 activation promoting MHC‐I engulfment by autophagosomes, aiding immune evasion. Here, ITGB4 is linked to familial pancreatic carcinoma.