To assess the ability of dazostinag to remodel the TME via induction of IFN signaling, NanoString GeoMx digital spatial profiling of ∼1,800 target genes from one patient sample (patient 2; lymph node tumor, metastatic disease; HPV status, positive; smoking status, never) at 24 hours after intratumoral injection was applied (Supplementary Information S1). This evidence concerns the gene IFNA1 and metastatic neoplasm.