TRIB3 and IgA glomerulonephritis: Furthermore, TRIB3 (log2FC = 3.9, padj = 3.3×10−10), involved in the palmitate-induced apoptosis pathway, and SERPINB7 (log2FC = 7.4, padj = 2.9×10−16), a serine proteinase inhibitor up-regulated in IgA nephropathy and thought to contribute to mesangial matrix accumulation by decreasing matrix metalloproteinase activities, were also significantly up-regulated (Figure 2).