Although TIC10 directly induces tumor cell apoptosis, LD‐EMs modulate the immune microenvironment by increasing the percentages of CD45+ lymphocytes, CD3+ T cells, M1 macrophages, and dendritic cells while reducing the percentages of M2 macrophages and MDSCs, suggesting the complementary and synergistic effects of TIC10 and LD‐EMs. Here, PTPRC is linked to neoplasm.