Another exampleof bioclick chemistry was reported by Bojarováet al., who developed biocompatible glyconanomaterials based on N-(2-hydroxypropyl)­methacrylamide(HPMA) copolymers for the specific targeting of galectin-3 (Gal-3).This protein is a promising target in cancer therapy because it isabundantly localized in tumor tissue and plays a crucial role in tumordevelopment and proliferation. However,the clinical application of Gal-3-targeted inhibitors is often challengedby issues of insufficient selectivity and low biocompatibility. This evidence concerns the gene LGALS3 and cancer.