POU5F1 and chronic obstructive pulmonary disease: There was a decrease of 40% in the transcript levels of POU5F1 in COPD samples at ALI7 (Fold change = 0.6, COPD vs. non-COPD, p < 0.01) but no difference between non-COPD and COPD samples at ALI35 (fold change = 1.2) (Figures 2B,C).