Besides, dysregulations of this pathway, characterized by sustained nuclear accumulation and transcriptional hyperactivation of YAP/TAZ, perturbs the tightly controlled equilibrium between cell proliferation and apoptosis, thereby driving tumor initiation, malignant progression, metastatic dissemination, and the development of therapeutic resistance (Harvey et al., 2013; Luo et al., 2023). The gene discussed is YAP1; the disease is neoplasm.