And in estrogen receptor alpha (ERα) positive breast cancer, YAP upregulates vestigial like family member 3 (VGLL3), recruiting the nuclear receptor co-repressor (NCOR2/SMRT) repressor to the estrogen receptor 1 (ESR1) super-enhancer, thereby silencing ERα transcription and inhibiting tumor growth (Ma et al., 2022). The gene discussed is ESR1; the disease is breast cancer.