In certain cases like clear cell renal cell carcinoma (ccRCC), YAP represses the TEAD-NF-κB complex by competing with TEAD for p65 binding, preventing p65 recruitment to target gene promoters to attenuate inflammation-driven tumorigenesis (Li et al., 2024). Here, NFKB1 is linked to nonpapillary renal cell carcinoma.