AREG and gastric cancer: CXCL2 upregulation is clinically relevant as this neutrophil chemoattractant is elevated in human gastric cancer and correlates with increased angiogenesis and tumor progression, while amphiregulin promotes epithelial proliferation and is frequently overexpressed in human gastric adenocarcinomas (Kasashima et al., 2017; Sawant et al., 2023; Li et al., 2017).