This timeline demonstrates the tumor suppressor function of NF-κB1 in the gastric epithelium, contrasting with its oncogenic role in many other cancers, and reflects the slow progression observed in human gastric cancer where precancerous lesions may take decades to progress to invasive carcinoma (Soutto et al., 2011; O'Reilly et al., 2018). This evidence concerns the gene NFKB1 and gastric cancer.