VWF and von Willebrand disease (hereditary or acquired): VWD requires individualized treatment based on specific diagnosis, bleeding phenotype, and specific clinical context.Major therapies include use of desmopressin to induce endothelial release of stored VWF and factor VIII and use of VWF concentrates, including both plasma-derived and recombinant products, as well as adjuvant therapies, such as antifibrinolytic tranexamic acid.Targeting specific mutations may further lead to personalized treatments in the future (17).