BMP4 and periodontitis, aggressive: Furthermore, another study has suggested the impact of BMP4 genetic polymorphism on early marginal bone loss surrounding dental implants.85 It has been reported that particular polymorphic genotypes of RANKL (rs9533156) can give rise to PI development among Iranians.14 However, SNPs in the genotype of RANKL exhibited no significant association with aggressive periodontitis in a Japanese population.86 The link between BRINP3 (rs1342913) and PI susceptibility has been delineated by Casado et al.41