However, the mentioned significant difference was not identified in a systematic review comparing PID risk in patients with or without gene polymorphism IL-10 -1082.24 Regarding periodontitis, a significant association with IL-10 -1082 gene polymorphism was reported only for Caucasians.73 Kadkhodazadeh et al44 have highlighted the potential contribution of IL17 (rs10484879) CC genotype to the pathogenesis of PI and periodontitis. The gene discussed is IL10; the disease is periodontitis.