TNFSF11 and periodontitis, aggressive: Consequently, the pathogenesis of these diseases exhibits high degrees of similarity.87 Given this, any significant association between IL-6 -174 gene polymorphism and the risk for periodontitis and gingivitis was refuted by Salman et al.88 Moreover, the link between SNPs in RANK, RANKL, and OPG genes and aggressive periodontitis was rebutted in the Japanese population.86