However, the mentioned significant difference was not identified in a systematic review comparing PID risk in patients with or without gene polymorphism IL-10 -1082.24 Regarding periodontitis, a significant association with IL-10 -1082 gene polymorphism was reported only for Caucasians.73 Kadkhodazadeh et al44 have highlighted the potential contribution of IL17 (rs10484879) CC genotype to the pathogenesis of PI and periodontitis. This evidence concerns the gene IL10 and pelvic inflammatory disease.