IL17A and pelvic inflammatory disease: However, the mentioned significant difference was not identified in a systematic review comparing PID risk in patients with or without gene polymorphism IL-10 -1082.24 Regarding periodontitis, a significant association with IL-10 -1082 gene polymorphism was reported only for Caucasians.73 Kadkhodazadeh et al44 have highlighted the potential contribution of IL17 (rs10484879) CC genotype to the pathogenesis of PI and periodontitis.