This variant has been reported in a small number of other cases, including a female patient with type 1 VWD in the US,26a male patient with type 3 VWD in Mexico,27a female patient with type 2M in Finland,28and a female patient with combined VWD and factor V deficiency in Germany.29The clinical impact of thep.Leu1365ProVWF variant including its relationship to the development of VWF inhibitors remains unknown. This evidence concerns the gene VWF and von Willebrand disease (hereditary or acquired).