This variant has been reported in a small number of other cases, including a female patient with type 1 VWD in the US,26a male patient with type 3 VWD in Mexico,27a female patient with type 2M in Finland,28and a female patient with combined VWD and factor V deficiency in Germany.29The clinical impact of thep.Leu1365ProVWF variant including its relationship to the development of VWF inhibitors remains unknown. Here, VWF is linked to von Willebrand disease 3.