LEP and endometriosis: Endometriosis pain is a very common and extremely disabling disorder for women, and it is still poorly understood.(1) Leptin, with its pro-inflammatory and neoangiogenic action, may play a role in the origin of the pain associated with the disease.(2,3) To date, there are no biochemical and genetic markers considered efficient and accurate to assist in the individualized treatment of these women, and this is a broad field of research that may provide new diagnostic and therapeutic strategies.