While numerous studies have explored antibody affinity against potential malaria antigen candidates for vaccine development, few have investigated how antibody affinity develops over extended periods in early infancy, particularly in comparison to maternal antibodies, This study aimed to evaluate the dissociation rate constant, kd (which correlates with affinity) of naturally acquired antibodies targeting key immune and vaccine antigens - AMA1, MSP2 and CSP. This evidence concerns the gene DNAJC5 and malaria.