TGFB1 and neoplasm: IL-10: IL-10 is a potent immunosuppressive factor that inhibits dendritic cell maturation and T-cell activity.TGF-β: TGF-β inhibits the multiplication and functionality of T cells, while promoting the differentiation and function of regulatory T cells. TGF-β production in the immunosuppressive microenvironment indirectly promotes tumor escape. Tumor cells escape immune surveillance by accumulating mutations that inhibit TGF-β signaling.