TLR1 and asthma: The aforementioned studies indicate that, on the one hand, TLR1 recognizes pathogens and is highly expressed in patients with asthma, suggesting its potential role in promoting inflammation or in the pathogenesis of asthma, but on the other hand, the TLR1/2 signaling pathway has been confirmed to have protective effects on asthma, and TLR1-specific gene polymorphisms are associated with either protection against asthma or risk of asthma.