Collectively, these studies demonstrate that TLR4, by bridging innate and adaptive immunity and responding to diverse stimuli (both PAMPs and DAMPs), plays a multifaceted role in asthma pathophysiology, influencing inflammation, immune deviation, inflammatory cell recruitment, airway remodeling, and hyperresponsiveness, establishing TLR4 as a critical regulatory node. This evidence concerns the gene TLR4 and asthma.