TLR1 and atopic asthma: confirmed that the TLR1 single-nucleotide polymorphisms (SNPs), such as rs5743594, rs5743595, and rs4833095, have a protective effect on atopic asthma (37), but the variant TLR1 rs5743618 may increase the risk of asthma at the age of 11–13 years after infant bronchiolitis (38, 39).