Of the 14 (6.1%) malignant tumors, 6 were lung cancer, 2 were ectopic adrenocorticotropin-secreting carcinoid, 1 was gastric cancer, 1 was prostate cancer, 1 was oral cancer, 1 was breast cancer, 1 was pancreatic cancer, and 1 was bladder cancer; 13 patients (5.7%) had rheumatoid arthritis. The gene discussed is POMC; the disease is breast carcinoma.