In an animal model constructed by Wang et al, it was found that USP39 overexpression reduced the sensitivity of ES2 cell line cells to cisplatin, whereas this effect was reversed following USP39 knockdown (44), indicating that USP39 expression levels influence cellular sensitivity to cisplatin, similar to the fact that knockdown of USP39 improves the sensitivity of gastric cancer cells to carboplatin. This evidence concerns the gene USP39 and gastric cancer.