For example, in HCC, USP39 not only specifically binds to molecules such as SP1 and ZEB1, removing ubiquitin chains to enhance their protein stability and thereby promoting tumor initiation and progression, but also impacts malignant tumor progression by regulating the pre-mRNA splicing of molecules such as AuroraB, FoxM1, and TRIM26. This evidence concerns the gene USP39 and hepatocellular carcinoma.