found that USP39 can bind to MRPL35 to exert a deubiquitylation effect and increase the overexpression of MRPL35 by preventing it from being degraded by the ubiquitin-proteasome pathway, which then promotes glutamine metabolism and tumor progression (57).The regulation of glutamine metabolism by USP39 suggests that USP39 may indirectly affect tumor development by regulating the tumor microenvironment, reflecting the diversity of mechanisms of tumor regulation by USP39. Here, USP39 is linked to neoplasm.