Furthermore, through microarray analysis in bioinformatics, the researchers found that USP39 was correlated with target genes such as IRF1, caspase 8 and SP1 (59), which play key regulatory roles in regulating tumor apoptosis and proliferation, suggesting that USP39 can influence tumor growth in leukemia cells by participating in various signaling pathways. The gene discussed is CASP8; the disease is neoplasm.