observed that the proliferation, invasion, migration and other functions of tumour cells were reduced, and further showed that the phosphorylation levels of Akt and ERK, key regulators of PI3K/Akt and MAPK/ERK signaling pathways, were also significantly reduced by Western blot, suggesting that USP39 may activate the relevant signaling pathways by regulating the phosphorylation levels of Akt and ERK (36). Here, USP39 is linked to neoplasm.