In endometrial cancer, USP39 is involved in a variety of mechanisms and pathways, not only interacting with PGK1 to improve the stability of PGK1, but also regulating the process of glycolysis by activating the PI3K/AKT/HIF-1α signaling pathway, and these modifications can effectively promote the growth and proliferation of tumor cells. This evidence concerns the gene USP39 and neoplasm.