AKT1 and neoplasm: observed that the proliferation, invasion, migration and other functions of tumour cells were reduced, and further showed that the phosphorylation levels of Akt and ERK, key regulators of PI3K/Akt and MAPK/ERK signaling pathways, were also significantly reduced by Western blot, suggesting that USP39 may activate the relevant signaling pathways by regulating the phosphorylation levels of Akt and ERK (36).