USP39 and neoplasm: showed that the ZnF (zinc finger) structural domain and the UCH1/UCH2 structural domains of USP39 were able to bind to the action site on SRSF1, driving VEGF-A pre-mRNA splicing through enhanced phosphorylation of SRSF1, thereby generating as many VEGF-A165a isoforms as possible to activate the angiogenic signalling pathway and promote tumour growth (37).