The results of the multiple logistic regression analysis showed that TNBC status (odds ratio [OR] = 3.408; 95% confidence interval [CI]: 1.026–11.321; P=0.045) and axillary lymph node metastasis (0.200; 0.068–0.593; P=0.004) were the independent predictors of IGF2BP3 expression in breast cancer. This evidence concerns the gene IGF2BP3 and breast cancer.