For example, in an IHC study of 138 invasive ductal carcinomas of the breast, tumors that were histologically high-grade, exhibited tumor necrosis, or were of the TNBC subtype showed significantly increased IGF2BP3 expression, and IGF2BP3 expression was associated with poor patient prognosis (10). Here, IGF2BP3 is linked to invasive ductal breast carcinoma.