At the time of follow-up, none of the patients exhibited clinical symptoms or complications, such as prenatal tumor rupture and bleeding, fetal heart enlargement, atrioventricular regurgitation, fetal anemia, fetal distress in utero, high-output heart failure and thrombocytopenia after birth, tumor rupture and bleeding, etc. And their AFP levels, thyroid function tests (TSH and free T4), and fibrinogen levels were within the normal ranges. The gene discussed is AFP; the disease is neoplasm.