SIRT1 and metabolic disease: For example, during metabolic disorders or inflammation, both Sirt1 and PPAR‐α may be upregulated in WBCs, reflecting changes in lipid metabolism in other tissues (Costa et al. 2021; Song et al. 2011; Xu et al. 2024; Zamaninour et al. 2017; Ameer et al. 2017).