Our findings revealed that TB supplementation significantly increased HDL‐c (0.34 ± 2.11 vs. −1.24 ± 3.09; p = 0.041), HDL‐c2 (0.95 ± 1.8 vs. −0.26 ± 1.30; p < 0.001), the HDL‐c2/HDL‐c3 ratio (0.04 ± 0.45 vs. 0.01 ± 0.04; p = 0.004), and the gene expression of PPAR‐α (0.884 ± 0.195 vs. 0.332 ± 0.178; p = 0.004) compared to the placebo. The gene discussed is PPARA; the disease is tuberculosis.