The Effect of Theobromine Supplementation on HDL‐c Subclasses (HDL‐c2, HDL‐c3), HDL‐c2/HDL‐c3 Ratio, and Gene Expression of PPAR‐α and Sirt1 in Subjects With Metabolic Syndrome: A Randomized Controlled Clinical Trial. This evidence concerns the gene SIRT1 and metabolic syndrome.