Vitamin A supplementation in the treatment of children with mycoplasma pneumoniae pneumonia can significantly improve the clinical efficacy, shorten the length of hospital stay, the disappearance time of pulmonary rales, the duration of cough and fever, reduce the levels of IL‐6 and IL‐10, reduce the inflammatory response, and does not increase the incidence of adverse reactions. This evidence concerns the gene IL6 and Mycoplasma pneumoniae pneumonia.