With respect to additional variants in PD-linked genes, seven of the 45 individuals carried GBA1 or LRRK2 risk variants, and two carried heterozygous pathogenic variants in recessively inherited PD genes (Table 2), but none harbored a disease-explaining variant in an established PD-linked gene (including LRRK2, SNCA, VPS35, RAB32, PINK1, PRKN, and PARK7/DJ-1). Here, PINK1 is linked to Parkinson disease.