Finally, 5·1% (999/19,539) of unaffected individuals, including unaffected family members of PD patients, harbored variants in GBA1 (n=936; 4·8%), especially E365K and T408M, LRRK2 (n=54; 0·3%), SNCA (n=3; 0·02%), and PRKN (n=1; 0·01%). This evidence concerns the gene GBA1 and Parkinson disease.