Consistent with these motor deficits, both Acbd5–/– models show cerebellar degeneration marked by Purkinje cell loss, pronounced axonal swellings, and demyelination of cerebellar white matter tracts (Darwisch et al., 2020; Granadeiro et al., 2024), which correlates with the cerebellar symptoms typically observed in RDLKD patients. The gene discussed is ACBD5; the disease is cerebellar degeneration.