TRPM2 and epilepsy: Considering the widespread expression of TRPM2 channel in the brain, both in neurons and microglia, to investigate the cell‐specific mechanism of TRPM2 channel in epilepsy, we construct Trpm2fl/fl mice (Figure 2A), then we breed Trpm2fl/fl mice with CaMKIIα‐Cre mice to selectively delete Trpm2 in CaMKIIα+ excitatory neurons (Figure 2B).