TRPM2 and epilepsy: Similar with the seizure behavior of Trpm2−/− mice, pharmacological inhibition of TRPM2 channel by antagonist A23 did not affect the onset of EEG seizure and latency to GS (Figure S2A,B), while led to a decreased latency to tonic seizure (Figure S2C) and an increased incidence of death (Figure S2D), suggesting the important role of TRPM2 channel involved in epilepsy.