TRPM2 and epilepsy: Indeed, inflammatory cytokines from both neurons and glia cells contribute to epilepsy [45], although the microglial TRPM2 deficiency can inhibit microglial activation, it cannot inhibit the release of inflammatory cytokines in epilepsy (later phase of seizure development), which increased the excitotoxicity and neuronal loss further promoted the release of inflammatory cytokines from all types of neural cells [45].