Mediation analysis showed that TG (proportion mediated 10.81%), HDL-C (proportion mediated 16.50%), ALB (proportion mediated 6.03%), UA (proportion mediated 19.06%), CRP (proportion mediated 3.42%), WBC (proportion mediated 7.65%), and neutrophil counts (proportion mediated 5.40%) significantly mediated the association between CircS and periodontitis (Figure 5). The gene discussed is ALB; the disease is periodontitis.