It is noteworthy that the activation of PI3K/Akt pathway can reshape the glucose metabolism state of cells (Wang et al., 2024), and its end product lactic acid can mediate histone lactation modification, and then regulate gene expression (Liberti and Locasale, 2020), which suggests that ERCC6L may indirectly affect histone lactation level through PI3K/Akt metabolic reprogramming axis, and then reshape the tumor microenvironment. This evidence concerns the gene ERCC6L and neoplasm.