To evaluate the relationship between five hub genes (TFRC, CP, SAT1, STEAP3, LPCAT3) and HF and AF, we collected serum samples from 27 patients (9 healthy, 9 with HF, and 9 with AF) at Huangshan Shoukang Hospital in Anhui Province, China. The gene discussed is STEAP3; the disease is atrial fibrillation.