By analyzing the transcriptional expression profiles of the GEO datasets, TFRC, CP, SAT1, STEAP3, AKR1C1 and LPCAT3 were identified as FRDEGs in AF and HF, which were revealed to be involved in iron ion transport, homeostasis, and oxidoreductase activity. The gene discussed is AKR1C1; the disease is atrial fibrillation.