Our results demonstrate that anti-tumor immune response cells (e.g., activated CD4 T cells, central memory CD8 T cells, and type 1/17 helper cells) exhibited higher levels of infiltration in low-risk patients, consistent with lower levels of immune suppressive cells (e.g., immature dendritic cells, neutrophils, plasmacytoid dendritic cells, and regulatory T cells) in these patients (Wilcoxon rank-sum test, all P < 0.05). Here, CD4 is linked to neoplasm.