It impedes cancer cell proliferation by modulating several critical oncogenic pathways (Wang et al., 2013), including the PI3K-Akt, HIF-1-VEGF, IKK-IKBa-NF-κB, EMT, and AMPK-mTOR-survivin signaling cascades (Yang et al., 2013). This evidence concerns the gene NFKB1 and cancer.