Downregulate the phosphorylation levels of Akt and GSK-3 β, promote the protein degradation of β -catenin, reduce its accumulation in the nucleus, and then inhibit the transcriptional activation of β -catenin non responsive genes, thus effectively inhibiting the growth, proliferation, invasion and migration of prostate cancer cells. It can also inhibit the expression of proliferation related proteins and anti-apoptotic proteins in prostate cancer cells. This evidence concerns the gene AKT1 and Familial prostate cancer.