In LNCaP and PC-3 human prostate cancer cells, deguelin promoted the protein degradation of β-catenin and reduced its accumulation in the nucleus by downregulating the phosphorylation levels of Akt and GSK-3 β, thereby inhibiting the transcriptional activation of β-catenin non responsive genes, thereby effectively inhibiting the growth, proliferation, invasion and migration of prostate cancer cells (Thamilselvan et al., 2011). The gene discussed is AKT1; the disease is prostate cancer.