Apoptosis of gastric cancer cells is induced by the activation of two key apoptotic pathways, caspase-9 and caspase-3.Deguelin demonstrated IC50 values of 11.83μM and 9.33 μM in MGC-803 and MKN-45 cells, respectively, after 72 h of treatment. The gene discussed is CASP3; the disease is gastric cancer.