In LNCaP and PC-3 human prostate cancer cells, deguelin promoted the protein degradation of β-catenin and reduced its accumulation in the nucleus by downregulating the phosphorylation levels of Akt and GSK-3 β, thereby inhibiting the transcriptional activation of β-catenin non responsive genes, thereby effectively inhibiting the growth, proliferation, invasion and migration of prostate cancer cells (Thamilselvan et al., 2011). This evidence concerns the gene AKT1 and Familial prostate cancer.