Promote cell cycle arrest at G2/M stage and induce apoptosis, reduce its proliferation activity, and inhibit the migration of GBM cells. Inhibiting the CCL2/NF-κB pathway in vivo to curb tumor growth and inhibit GBM angiogenesis.The IC50 of deguelin on DBTRG cells after 24 h was 4.178 μM, and the IC50 of deguelin on C6 cells after 12 h was 1.953 μM. Here, CCL2 is linked to glioblastoma.