SLIT2 and lung adenocarcinoma: In lung adenocarcinoma A549 cells, deguelin reduced the expression of MMP-2 and MMP-9 by downregulating slit guidance ligand 2/roundabout 2 receptor (slit2/robo2) and its downstream targets, which in turn affected the amount and morphology of cytoskeletal protein F-actin, and ultimately reduced the proliferation, invasion and migration ability of cells (Zhou H. H, et al., 2020).