TYR and melanoma: In the future, we need to focus on three major directions: 1 establishing a multi-dimensional screening platform (such as 3D melanocyte models) to accelerate the rational design of humanized peptides; 2 Developing a cyclic peptide-liposome co-delivery system to break through the skin barrier and enhance targeting; 3 Identify the regulatory nodes of TYR in melanoma signal pathway through organ-like and preclinical studies, and promote the transformation from basic research to therapeutic application.