Furthermore, studies indicate that inhibition of the PI3K/AKT/mTOR pathway enhances melanoma cell sensitivity to the chemotherapy drug temozolomide (TMZ), suggesting that combining bee venom with TMZ could lead to a more potent inhibitory effect on melanoma (Sinnberg et al., 2009; Niessner et al., 2017). The gene discussed is AKT1; the disease is melanoma.