Western blot analysis of both cultured cells and xenograft tumor tissues revealed that PPVI/PPVII treatment upregulated pro-apoptotic regulators (p53, p21WAF1/CIP1), death receptors (DR3, DR5, Fas), and apoptosis execution markers (cleaved PARP, caspase-3), while downregulating cell cycle promoters cyclin B1 and decoy receptor DcR3. The gene discussed is FAS; the disease is neoplasm.