Xiong et al. (2019) previously demonstrated that HSD upregulates PPAR-α expression in the adipose and liver tissues. This study is the first to document a significant increase in PPAR-α levels in the heart tissues of HSD-treated rats, suggesting further protection from hypothyroidism-related dyslipidemia and cardiac inflammation. Interestingly, PPAR-α is one of the T3-regulated genes, and the activation of PPAR-α may restore TR expression and THs functionality (Lu and Cheng, 2010). Here, PPARA is linked to hypothyroidism.