Concomitantly, elevated IgE production sustains a self-perpetuating Th2 inflammatory cascade, clinically characterized by peripheral blood eosinophilia, increased serum total IgE, Aspergillus-specific IgE seropositivity, and pulmonary eosinophilic infiltration (Luo et al., 2024; Moss, 2005). Here, IGHE is linked to Increased total eosinophil count.