ATOX1 also promotes growth of BRAFV600E expressing melanoma cells, though its effect on ERK1/2 phosphorylation was proposed to be indirect.22 In our study, both MEK1/2 kinases were detected as APEX2-ATOX1 proximal proteins in myoblasts (Figure 4A and Supplementary Table 2). Here, ATOX1 is linked to melanoma.