SST and Alzheimer disease: A previous single-cell RNA-sequencing study of lenti AD neurons predominantly found SST+ neurons at 4 WPI, but later time points were not investigated.66 Perhaps CGE markers only appear further along the maturation process, or transcriptomics do not accurately reflect the molecular identity of these neurons.67–69 To further restrict and direct subtype specification during PB-AD induction, additional patterning with small molecules, which was recently developed for safe harbor-AD induction, could potentially be employed.70