Querying Open Targets identified the association of TJP1 with cortical surface area(43), EMC4 with cognitive ability (44), GOLM2 with neuritic plaque (45), SORD with cortical thickness (46), COPS2 with cortical thickness (46), HERC1 with Alzheimer’s disease (47), and UBE2Q2 with cortical surface area (43). This evidence concerns the gene EMC4 and early-onset autosomal dominant Alzheimer disease.