The downregulation of Bcl2 is significant which can be caused by the effect of lupeol (Prasad et al. 2018), as Bcl2 is a key anti-apoptotic protein that prevents mitochondrial membrane permeabilization and cytochrome c release with recent research demonstrating that Bcl2 downregulation is essential for effective cancer therapy and is associated with improved treatment outcomes (Singh et al. 2019). The gene discussed is BCL2; the disease is cancer.