Indeed, in Japanese peritoneal dialysis guidelines, dry weight is currently determined clinically with reference to the absence edema, the absence pleural effusion or pulmonary congestion on chest X-Ray, CTR <50%, atrial natriuretic peptides (ANP) 50-100 pg/mL, inferior vena cava diameter and respiratory variability [25]. The gene discussed is NPPA; the disease is Pleural effusion.