NFE2L2 and cervical squamous intraepithelial neoplasia: The kidney mounts a compensatory antioxidant response via nuclear factor erythroid 2-related factor 2 (Nrf2), but in severe CIN, this defense can be overwhelmed; indeed, loss of Nrf2 function exacerbates contrast-induced ROS accumulation and cell death, whereas Nrf2 activation attenuates tubular injury [2].