Licorice mucoadhesive film mitigates oral mucositis primarily by delivering glycyrrhizin directly to ulcerated mucosa, where it inhibits NF-κB-mediated cytokine production and reduces COX-2 expression, while the mucoadhesive matrix ensures prolonged contact for sustained anti-inflammatory and epithelial-healing effects. This evidence concerns the gene NFKB1 and oral mucositis.