In comparing Group 2 to Group 1, the following characteristics were noted in Group 2: reduced height and weight SDs, an elevated percentage of patients exhibiting low body weight, an increased prevalence of patients with hypogonadism and IGF-1<-2SD, a higher proportion of patients with low bone mass, notably elevated SF concentrations and enhanced CID, a greater incidence of splenectomy, elevated lumbar spine BMD values despite significantly reduced corresponding Z-scores, lower Hb levels, elevated TG and diminished HDLC, increased FPG and INS levels, and diminished 25(OH)D levels (Table 2). The gene discussed is IGF1; the disease is hypogonadism.