Notably, significant crosstalk exists among multiple programmed cell death (PCD) pathways in osteoporosis; within mitochondrial regulation of OP-related PCD, mitochondria coordinate apoptosis through Bcl-2 family proteins and necroptosis via RIPK1/3 signaling, with these two pathways maintaining dynamic equilibrium that collectively impacts bone homeostasis (69). The gene discussed is BCL2; the disease is osteoporosis.