This mutation was selected based on previous findings indicating a positive selection of deleterious truncating MT-ND5 mutations in kidney, colorectal, and thyroid cancers.39MT-ND5, the longest mtDNA-encoded gene and a major subunit of mitochondrial Complex I, was selected as it is the most mutated mtDNA-encoded coding gene.47 Here, MT-ND5 is linked to thyroid gland carcinoma.