The spatial localization of HYP peptides for COL1A1, COL1A2, COL5A1 and COL3A1 exhibited distinct region-specific patterns in dormant D-HEp3 compared to awakened P4HA2-depleted D-HEp3 cells (Fig. 3c), suggesting differential regulation of collagen hydroxylation across tumor zones. This evidence concerns the gene COL5A1 and neoplasm.