To determine the impact of 4HYP-modified collagen matrix produced by P4HA2-depleted cells on tumor cell quiescence, we generated decellularized matrix scaffolds from D-HEp3 nodules or P4HA2-depleted D-HEp3 awakened tumors and seeded D-HEp3 cells expressing a CDK2 biosensor onto them (Fig. 3d). Here, CDK2 is linked to neoplasm.