SH2D3C and Zika virus infectious disease: As ZIKV infection modifies the intracellular membranes, NS2A localizes on the tubular ER membrane and, in large ER-associated vesicles, accumulates in the perinuclear region during late infection.35 In contrast, CHIKV nsP3 can be observed on the plasma membrane where early-stage (3–6 h.p.i.)replication and translation occur, as well as on endosomal membranes, lysosomes, and large type I cytoplasmic vesicles (CPV-I) during later time points.19,71,72