DDX5 was shown to be a proviral factor, relocalizing from the nucleus to the cytoplasm in association with viral RNA in SINV.80 More broadly, DDX5 serves a known proviral function by suppressing the IFN response, thereby promoting virus infection in several viruses, including SARS-CoV, HCV, JEV, and IFV.81 Here, DDX5 knockdown in U2OS cells reduced virus replication, indicating a proviral effect. This evidence concerns the gene DDX5 and viral infectious disease.