AQP4 and neurodegenerative disease: The frequent citation of high-impact journals such as “Science Translational Medicine” (cited 470 times), “Journal of Neuroscience” (445 times), and “Science” (440 times) not only reflects the core position of basic mechanism research (such as AQP4 polarization regulation and CSF dynamics) but also reflects the deep integration trend between GS theory and clinical research on neurodegenerative diseases.