AQP4 and Alzheimer disease: The study pioneeringly revealed the direct association between GS dysfunction and tau protein clearance disorders in a tau-lesion mouse model, clearly clarified the key regulatory role of AQP4 polarization in the glymphatic-mediated tau clearance process, and found a correlation between brain-region-specific glymphatic function differences and tau pathological distribution, providing new molecular targets and potential treatment directions for AD pathogenesis research (Benveniste et al., 2017).