At the same time, the study integrated the synergistic damaging effects of factors such as cardiovascular health, abnormal AQP4 localization, and decreased sleep quality on glymphatic function, and pointed out that improving sleep or targeting enhanced glymphatic clearance ability may become a new strategy for treating neurodegenerative diseases (Nedergaard and Goldman, 2020). Here, AQP4 is linked to neurodegenerative disease.