The study pioneeringly revealed the direct association between GS dysfunction and tau protein clearance disorders in a tau-lesion mouse model, clearly clarified the key regulatory role of AQP4 polarization in the glymphatic-mediated tau clearance process, and found a correlation between brain-region-specific glymphatic function differences and tau pathological distribution, providing new molecular targets and potential treatment directions for AD pathogenesis research (Benveniste et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.