Around 90–95% of thecases are sporadic with no apparent genetic link (sporadic ALS, sALS),while the remaining 5–10% of the cases are related to severalgenetic mutations (familiar ALS, fALS). Since the first gene was discovered in fALS, superoxide dismutase1 (SOD1) more than 200 genetic variants of this gene, has been reported(https://alsod.ac.uk/output/variant.php/35). Here, SOD1 is linked to amyotrophic lateral sclerosis.